High MET gene copy number predicted poor prognosis in primary intestinal diffuse large B-cell lymphoma

BACKGROUND: MET is a proto-oncogene with its copy number (CN) alterations been reported in some cancers, but not in primary intestinal diffuse large B-cell lymphoma (PI-DLBL) yet. METHODS: In this retrospective study, we performed histology and chart reviews, immunohistochemistry and quantitative polymerase chain reaction for MET CN alterations on 28 surgically resected PI-DLBLs. RESULTS: There were 12 men and 16 women with a median age of 70 and a mean follow-up of 32 months. The median MET CN was 2.20 (range, 1.04 to 3.35). CN gain was observed in 11 cases, including 5 with CN greater than 3. Nine patients (32%) had diploid CN and eight (29%) with CN loss. Patients with gain or diploid CN showed significantly worse prognosis (P = 0.046) than those with CN loss. Furthermore, MET CN greater than 3 was associated with an adverse outcome (P = 0.003). Intestinal perforation at presentation was the sole clinicopathological factor associated with a poor prognosis (P = 0.004) and perforation was correlated with CN greater than 3 (P = 0.002). CONCLUSIONS: Our finding of MET CN gain as a poor prognostic factor in PI-DLBL patients might serve as the rationale for targeting MET signaling pathway in the treatment of these patients

Idiopathic Superior Mesenteric Vein Thrombosis Resulting in Small Bowel Ischemia in a Pregnant Woman

Background. Small bowel ischemia due to superior mesenteric vein thrombosis (MVT) is rare during pregnancy. However, additional precipitating factors should usually be identified. Case. A 31-year-old woman, pregnant at 34 weeks, was sent to the emergency department because of acute peritonitis. An emergency exploration revealed a segmental gangrene of the small intestine without any mechanical obstruction. Together with the termination of pregnancy, resection of the damaged small bowel was performed, and an end-to-end enterostomy was followed. Based on the operative and pathological findings, small bowel ischemia might be attributed to superior mesenteric vein thrombosis. Conclusion. Hypercoagulation state normally found in pregnant women is believed to lead to this catastrophic condition without other precipitating factors

Structural response reconstruction for non-proportionally damped systems in the presence of closely spaced modes

An approach of structural response reconstruction for non-proportionally damped systems is proposed in this paper, which is a time domain method based on the empirical mode decomposition method with intermittency criteria and modal superposition method. The state space method is employed for decoupling the dynamic system equation to obtain the complex mode shapes. Response reconstruction of the structural system in the presence of closely spaced modes is studied in detail. The key idea is to regard each set of closely spaced modes as an integral part. Two numerical examples are conducted to validate the effectiveness of the proposed method

Primary Pulmonary Synovial Sarcoma: A Case Report

We report a rare case of primary synovial sarcoma of the lung. A 57-year-old man had a well-defined tumor in the right middle lobe seen on chest computed tomography, and underwent lobectomy. Grossly, the nonencapsulated tumor measured 4.5 cm in greatest diameter, with a solid and tan-white cut surface. Histologically, the tumor was mainly composed of a dense proliferation of spindle cells. Immunohistochemical studies were focally positive for epithelial membrane antigen, and diffusely positive for CD99 and Bcl-2. Cytokeratin, S-100 protein, desmin, smooth muscle actin, and CD34 were absent. SYT-SSX1 gene fusion transcript was detected by reverse transcription-polymerase chain reaction, which is diagnostic of primary synovial sarcoma of the lung. We also review the literature with regard to the clinicopathologic, immunohisto-chemical, and molecular studies of primary pulmonary synovial sarcoma

Non-linear response of temperature-related mortality risk to global warming in England and Wales

Climate change is expected to lead to changes in seasonal temperature-related mortality. However, this impact on health risk does not necessarily scale linearly with increasing temperature. By examining changes in risk relative to degrees of global warming, we show that there is a delayed emergence of the increase in the summer mean mortality risk in England and Wales. Due to the relatively mild summer mean temperatures under the current climate and the non-linearity of the exposure-response relationships, minimal changes in summer mean risk are expected at lower levels of warming and an escalation in risk is projected beyond 2.5°C of global warming relative to pre-industrial levels. In contrast, a 42% increase in mortality risk during summer heat extremes is already expected by 2°C global warming. Winter attributable mortalities, on the other hand, are projected to decrease largely linearly with global warming in England and Wales

Impact of sudden stratospheric warmings on United Kingdom mortality

Sudden stratospheric warmings (SSWs) during boreal winter are one of the main drivers of sub‐seasonal climate variability in the Northern Hemisphere. Although the impact of SSW events on surface climate and climate extremes has been clearly demonstrated, the impact of the resulting climate anomalies on society has not been so widely considered. In the United Kingdom (UK), SSWs are associated with cold weather, which is linked to significant increases in mortality. This study demonstrates, for the first time, that SSWs are linked to increases in mortality in the UK. A distributed lag nonlinear model and standard parameter settings from the literature is used to construct a daily time series of UK deaths attributable to cold weather between 1991 and 2018. Weekly mortality associated with SSWs is diagnosed using a superposed epoch analysis of attributed mortality for the 15 SSW events in this period. SSW associated mortality peaks between 3 and 5 weeks after SSW central date and leads to, on average, 620 additional deaths in the same period. Given that the impacts of SSWs can be skilfully predicted on sub‐seasonal timescales, this suggests that health and social care systems could derive substantial benefit from sub‐seasonal forecasts during SSWs

Emergence of topological phases from the extension of two-dimensional lattice with nonsymmorphic symmetries

Young and Kane have given a great insight for 2D Dirac semimetals with nontrivial topology in the presence of nonsymmorphic crystalline symmetry. Based on one of 2D nonsymmorphic square lattice structures they proposed, we further construct a set of 3D minimal tight-binding models via vertically stacking the 2D nonsymmorphic lattice. Specifically, our model provides a platform to generate three topologically semimetallic phases such as Dirac nodal line semimetals, Weyl nodal line semimetals and Weyl semimetals. The off-centered mirror symmetry sufficiently protects nodal lines emerging within mirror-invariant plane with a nontrivial mirror invariant $n_{M\mathbb{Z}}$, whereas twofold screw rotational symmetry protects nontrivial Weyl nodal points with topological charge $C=2$. Interestingly, Weyl nodal loops are generated without mirror symmetry protection, where nontrivial "drumhead" surface states emerge within loops. In the presence of both time-reversal and inversion symmetries, the emergence of weak topological insulator phases is discussed as well.Comment: 8 pages, 6 figures and 1 tabl